“International Medical Service in Egypt.”

Brain natriuretic peptide (BNP), a cardiac marker for the rapid detection of congestive heart failure

Brain natriuretic peptide, BNP, is stored primarily in ventricular myocardium and is released when ventricular diastolic pressure rises. BNP increases cardiac output by decreasing systemic and pulmonary vascular resistance. In addition, BNP reduces the production of renin and aldosterone by increasing renal blood flow, glomerular filtration rate, and renal output.

The following are indications for measuring plasma BNP:

Diagnosis of Cases of Heart Failure
Determination of plasma levels BNP is very useful in the diagnosis of early cases heart failure. A normal level of BNP in an untreated patient is extremely useful in excluding heart failure. Measurement of BNP has a potential role in screening systemic sclerosis patients for pulmonary arterial hypertension and in monitoring response to treatment.

Prognosis of Cases of Heart Failure
Plasma levels of BNP strongly positively correlate with the severity of heart failure.

Follow up of Cases of Heart Failure
Improvement of heart failure in response to treatment is associated with lowering of the plasma level of BNP.

Prognosis of Cases of Acute Myocardial Infarction
BNP secretion is associated with adverse ventricular remodeling and poor prognosis in cases of AMI.

Measurement of plasma BNP level is now available in Alfa Laboratories; the result can be obtained within 6 hours.

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